Valproate treatment of human cord blood CD4-positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4-positive cells through inhibition of histone deacetylase.

@article{FayyadKazan2010ValproateTO,
  title={Valproate treatment of human cord blood CD4-positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4-positive cells through inhibition of histone deacetylase.},
  author={Hussein Fayyad-Kazan and R{\'e}douane Rouas and Makram Merimi and Nabil el Zein and Philippe Lewalle and Fadi Jebbawi and Mohamad Mourtada and Hussein M Badran and Mohamad Ezzeddine and Bruno Salaun and Pedro Romero and Ars{\`e}ne Burny and Philippe Martiat and Bassam M Badran},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 27},
  pages={20481-91}
}
Regulatory T cells (Tregs) play a key role in immune system homeostasis and tolerance to antigens, thereby preventing autoimmunity, and may be partly responsible for the lack of an appropriate immune response against tumor cells. Although not sufficient, a high expression of forkhead box P3 (FOXP3) is necessary for their suppressive function. Recent reports have shown that histones deacetylase inhibitors increased FOXP3 expression in T cells. We therefore decided to investigate in non-Tregs CD4… CONTINUE READING