Valproate protective effects on cisplatin-induced peripheral neuropathy: an in vitro and in vivo study.

Abstract

BACKGROUND Antineoplastic drugs, such as cisplatin (CDDP), induce disabling peripheral neuropathies, representing a hindrance to effective cancer treatments. The exact pathogenesis of CDDP-induced neuropathy is not yet understood, and the dysregulation of gene expression has been proposed. Valproate (VPA) is an antiepileptic drug recently discovered to… (More)

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