Valproate prevents the induction of sensitization to methylphenidate (ritalin) in rats.

  title={Valproate prevents the induction of sensitization to methylphenidate (ritalin) in rats.},
  author={Pamela Yang and Allyson Beasley and Kary Eckermann and Alan C. Swann and Nachum Dafny},
  journal={Brain research},
  volume={887 2},
Repetitive exposure to methylphenidate (MPD) elicits sensitization to its locomotor effects. Drugs that affect the GABA system may modify adaptations to drug exposure. Therefore, we have examined the effect of sodium valproate, which enhances GABA function, on the development of sensitization to MPD using an automated, computerized animal activity monitoring system to record each rat's motor activities for 15 consecutive days. Rats were recorded before and after saline injection (Days 1-2) to… CONTINUE READING


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