Valproate is an effective, well‐tolerated drug for treatment of status epilepticus/serial attacks in adults

@article{Olsen2007ValproateIA,
  title={Valproate is an effective, well‐tolerated drug for treatment of status epilepticus/serial attacks in adults},
  author={Ketil Berg Olsen and Erik Taub{\o}ll and Leif Gjerstad},
  journal={Acta Neurologica Scandinavica},
  year={2007},
  volume={115}
}
Objective – Status epilepticus (SE) and serial attacks (SA) represent neurological emergencies, and mortality rate for SE/SA is high, ranging from 3% to 25%, depending on cause and co‐morbidity. As SE/SA become more refractory to treatment over time, rapid, appropriate treatment is extremely important. Here, we report a prospective registration of the effect of intravenous (IV) valproate (VPA) on SE/SA in a group of Norwegian patients. 
Status epilepticus: A critical review
Status epilepticus in adults.
Intravenous levetiracetam as treatment for status epilepticus
TLDR
Levetiracetam i.v. seems to be safe with relevant efficiency for the treatment of SE in elderly and multimorbid patients when comorbidity and respiratory insufficiency precludes high doses of benzodiazepines or phenytoin.
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin
Objective –  To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with
Review: Recent and future advances in the treatment of status epilepticus
TLDR
The current standard treatment ofStatus epilepticus is reviewed including recent advances and a summary of preclinical and clinical data regarding treatment options which may become available in the near future are provided.
The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus
TLDR
The treatment of SE is correlated with the modern understanding of the underlying neurophysiology and seizure duration, and parenteral antiepileptic drugs includingvalproate, levetiracetam are linked.
INTRAVENOUS VALPROIC ACID FOR THE TREATMENT OF STATUS EPILEPTICUS AND SEIZURE CLUSTERS
TLDR
Investigating the efficacy and tolerability of intravenous (IV) administration of Valproic acid (IV VPA) in the treatment of status epilepticus and SCs found it to be a safe, effective treatment, especially in patients with co-morbidities (cardiovascular diseases and respiratory insufficiency).
Drugs Commonly Used to Treat Refractory Status Epilepticus in Clinical Practice
TLDR
Polytherapy may be considered a feasible choice for treating RSE when single-drug treatment for SE fails, and seven drugs that are commonly used to treat RSE are described.
Status Epilepticus-Work-Up and Management in Children.
TLDR
The diagnostic work-up should start simultaneously to initial treatment, or as soon as possible, to detect potentially treatable causes of SE, a life-threatening medical emergency in which prompt and efficacious treatment may improve outcomes.
Efficacy and Safety of Intravenous Valproate for Status Epilepticus: A Systematic Review
TLDR
The published experience is consistent with VPA being a safe and effective therapeutic option for patients with established SE who have previously failed conventional first-line treatment with benzodiazepines, but high-quality randomized controlled trials are needed to inform clinicians on its comparative effectiveness in SE.
...
1
2
3
4
...

References

SHOWING 1-10 OF 20 REFERENCES
Generalized Convulsive Status Epilepticus: Causes, Therapy, and Outcome in 346 Patients
TLDR
Clonazepam, diazepam, and phenytoin were most frequently used for treatment and 68% had had epilepsy previously, according to underlying cause.
Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus
TLDR
This work reports on 41 children with therapy-resistant SE treated with IV VPA, one of the major antiepileptic drugs, with a broad efficacy for treatment of both generalized and partial seizures in children and adults.
Status epilepticus at an urban public hospital in the 1980s
TLDR
The clinical course of adult patients treated for generalized status epilepticus at the San Francisco General Hospital from 1980 to 1989 is reviewed to determine whether the etiologies of SE have changed over the last two decades, and to investigate the relationships between etiology, response to anticonvulsant therapy, and short-term clinical outcome.
Safety of intravenous valproate
TLDR
At the dosages and rates of administration studied, intravenous valproate appears to be safe and well tolerated.
Incidence of Status Epilepticus in Adults in Germany: A Prospective, Population‐Based Study
TLDR
To determine the incidence and case‐fatality rate of status epilepticus in adults in Hessen, Germany, a prospective, population‐based study was performed from July 1997 through June 1999.
Sodium valproate vs phenytoin in status epilepticus: A pilot study
TLDR
These considerations illustrate the difficulty of recruiting a suitable sample size to study the pharmacologic treatment of status epilepticus, and reinforce the need for a large, collaborative multicenter trial.
Incidence and Short‐term Prognosis of Status Epilepticus in Adults in Bologna, Italy
TLDR
To determine the incidence and the 30‐day case fatality of status epilepticus in the adult resident population of the city of Bologna, Italy, the objective was to establish a baseline level of awareness of the disease.
It's Time to Revise the Definition of Status Epilepticus
TLDR
A revised system for defining status epilepticus is proposed that aims to clarify the situation in which a seizure persists for a sufficient length of time or is repeated frequently enough to produce a fixed and enduring epileptic condition.
...
1
2
...