Valproate is an anti-androgen and anti-progestin

  title={Valproate is an anti-androgen and anti-progestin},
  author={A. Death and K. C. McGrath and D. Handelsman},
  • A. Death, K. C. McGrath, D. Handelsman
  • Published 2005
  • Biology, Medicine
  • Steroids
  • Anti-convulsant treatment is associated with a high prevalence of reproductive dysfunction compared with age-matched non-epileptics. We examined the widely used anti-convulsants valproate (VPA) and carbamazepine (CBZ) for steroidal bioactivity using a yeast-based steroid receptor-beta-galactosidase reporter assay for the androgen receptor (AR), progesterone receptor (PR) or estrogen receptor (ER). Bioassays were performed (a) to detect agonist activity by exposing yeast to 100 microM CBZ or VPA… CONTINUE READING
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