• DOI:10.1016/j.steroids.2005.07.003
Corpus ID: 25958985

Valproate is an anti-androgen and anti-progestin

@article{Death2005ValproateIA,
  title={Valproate is an anti-androgen and anti-progestin},
  author={A. Death and K. C. McGrath and D. Handelsman},
  journal={Steroids},
  year={2005},
  volume={70},
  pages={946-953}
}

A. Death, K. C. McGrath, D. Handelsman

Published 2005

Biology, Medicine

Steroids

Anti-convulsant treatment is associated with a high prevalence of reproductive dysfunction compared with age-matched non-epileptics. We examined the widely used anti-convulsants valproate (VPA) and carbamazepine (CBZ) for steroidal bioactivity using a yeast-based steroid receptor-beta-galactosidase reporter assay for the androgen receptor (AR), progesterone receptor (PR) or estrogen receptor (ER). Bioassays were performed (a) to detect agonist activity by exposing yeast to 100 microM CBZ or VPA… CONTINUE READING

View on Elsevier

opus.lib.uts.edu.au

Save to Library

Create Alert

Cite

Launch Research Feed