Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials.

@article{Basan2004ValproateAA,
  title={Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials.},
  author={Anja Basan and Werner Kissling and Stefan Leucht},
  journal={Schizophrenia research},
  year={2004},
  volume={70 1},
  pages={33-7}
}
Randomized controlled trials comparing valproate (as a sole, or as an adjunctive compound) to placebo for patients with schizophrenia or schizophrenia-like disorders were summarized in a metaanalysis. It was possible to include only five trials (n = 379) examining valproate as add-on to antipsychotics in this review. Some of the single studies showed inconsistent beneficial effects on some aspects of response, but no overall superiority of valproate augmentation at study endpoints was shown. 

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