Valproate and valproate-analogues: potent tools to fight against cancer.

@article{Blaheta2002ValproateAV,
  title={Valproate and valproate-analogues: potent tools to fight against cancer.},
  author={Roman A Alexander Blaheta and Heinz Nau and Martin Michaelis and Jindrich Cinatl},
  journal={Current medicinal chemistry},
  year={2002},
  volume={9 15},
  pages={
          1417-33
        }
}
The branched-chain fatty acid valproic acid (VPA) is the most commonly used antiepileptic drug for treating generalized epilepsy. Although originally considered to be of low toxicity, VPA has proved to possess considerable teratogenic potential when applied to the pregnant epileptic women. During the last few years, it has become evident that some of the mechanisms which account for the malformations produced by VPA are related to distinct anti-tumor properties of this compound. This intriguing… CONTINUE READING