Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma.

@article{Vandermeers2009ValproateIC,
  title={Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma.},
  author={Fabian Vandermeers and Pascale Hubert and Philippe Delvenne and Celine M Mascaux and Bogdan Dragoş Grigoriu and Ars{\`e}ne Burny and Arnaud Scherpereel and Luc N. A. Willems},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 8},
  pages={
          2818-28
        }
}
PURPOSE Present chemotherapeutic regimens are marginally efficient in tumor cells being particularly resistant to radiotherapy and/or chemotherapy. We hypothesized that unresponsiveness of tumors to conventional therapeutic agents might be due to inappropriate gene expression resulting from epigenetic modifications and leading to transcriptional silencing. The goal of this study was to evaluate the anticancer effect of a histone deacetylase inhibitor, valproate, on mesothelioma cells in… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

Histone deacetylase inhibitor SAHA induces ER a degradation in breast cancer MCF - 7 cells by CHIP - mediated ubiquitin pathway and inhibits survival signaling

  • X Yi, WeiW, SY Wang, ZY Du, XuYJ, XD Yu
  • Biochem Pharmacol
  • 2008

The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT - 29 cells

  • RussoT Portanova P, O Pellerito
  • Int J Oncol
  • 2008

Histone deacetylase inhibitors in cancer therapy

  • RasheedWK, RW Johnstone, HM Prince
  • Expert Opin Investig Drugs
  • 2007

proic acid induces apoptosis in chronic lymphocytic leukemia cells through activationof the death receptor pathway and potentiatesTRAIL response

  • A Insinga, S Monestiroli, S Ronzoni
  • 2007

Potential role of histone deacetylase inhibitors in mesothelioma : clinical experience with suberoylanilide hydroxamic acid

  • CurleyT Krug LM, L Schwartz
  • Clin Lung Cancer
  • 2006

Similar Papers

Loading similar papers…