Cortical sources of resting state EEG rhythms are sensitive to the progression of early stage Alzheimer's disease.
AIMS To evaluate the use of quantitative EEG (qEEG) statistical pattern recognition in diagnosing Alzheimer's disease (AD). METHODS qEEG was performed on 104 patients referred to a memory clinic. The qEEG results were compared to the clinical diagnosis made without access to the EEG results. RESULTS Of 30 patients with a clinical diagnosis of AD, 22 were test positive. Of the 74 patients without AD, 34 were test negative. The qEEG result was found to correlate with atrophy of the medial temporal lobe demonstrated on cerebral MRI (p = 0.002) and with scores on neuropsychological tests. CONCLUSION The qEEG was poor at diagnosing AD, as it produced many false-positive results.