Validity of the calculation of non-sex hormone-binding globulin-bound estradiol from total testosterone, total estradiol and sex hormone-binding globulin concentrations in human serum.

@article{Belgorosky1987ValidityOT,
  title={Validity of the calculation of non-sex hormone-binding globulin-bound estradiol from total testosterone, total estradiol and sex hormone-binding globulin concentrations in human serum.},
  author={Alicia Belgorosky and Mar{\'i}a Eugenia Reyes Escobar and Marco Aurelio Rivarola},
  journal={Journal of steroid biochemistry},
  year={1987},
  volume={28 4},
  pages={
          429-32
        }
}
Recent evidences indicate that biologically available serum testosterone (T) and estradiol (E2) include not only the free fractions but also most of the albumin-bound fractions. These two serum T or E2 fractions constitute most of non-sex hormone-binding globulin (SHBG)-bound T or E2, respectively. It has been reported that the estimation of serum non-SHBG-bound T gives identical results when it is assayed experimentally or when it is calculated by a formula derived from the law of mass action… CONTINUE READING

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