Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease.

@article{Kay2006ValidityAU,
  title={Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease.},
  author={Denise M Kay and Tom D Bird and Cyrus P Zabetian and S A Factor and A. Samii and Donald S. Higgins and John G. Nutt and John W. Roberts and A. Elizabeth Griffith and Berta C. Leis and Jennifer S. Montimurro and Sean M Philpott and Haydeh Payami},
  journal={Genetic testing},
  year={2006},
  volume={10 3},
  pages={221-7}
}
The G2019S mutation in the LRRK2 gene, the most common known cause of Parkinson's disease (PD), will soon be widely available as a molecular clinical test for PD. The objective of this study was to assess performance characteristics of G2019S as a clinical test for PD in the setting of typical movement disorder clinics in the United States. Subjects included 1,518 sequentially recruited PD patients from seven movement disorder clinics in the United States, and 1,733 unaffected subjects. All 3… CONTINUE READING
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