Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients

  title={Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients},
  author={Johanna G H van Nes and Vincent T. H. B. M. Smit and Hein Putter and Peter J K Kuppen and Seung Jim Kim and Motonari Daito and Jiaan Ding and Masami Shibayama and Shigehiro Numada and Keigo Gohda and Takamitsu Matsushima and Hideki Ishihara and Shinzaburo Noguchi and Cornelis J. H. van de Velde},
  journal={British Journal of Cancer},
  pages={494 - 500}
In a Japanese study, cyclin-dependent kinase (CDK) based risk determined by CDK 1 and 2 activities was associated with risk of distance recurrence in early breast cancer patients. The aim of our study was to validate this risk categorization in European early breast cancer patients. We retrospectively analyzed frozen breast cancer specimens of 352 Dutch patients with histologically confirmed primary invasive early breast cancer. CDK-based risk was determined in tumour tissues by calculating a… CONTINUE READING
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