Validation of whole blood impedance aggregometry as a new diagnostic tool for HIT: results of a large Australian study.

@article{MorelKopp2012ValidationOW,
  title={Validation of whole blood impedance aggregometry as a new diagnostic tool for HIT: results of a large Australian study.},
  author={Marie-Christine Morel-Kopp and Chee Wee Tan and Timothy A Brighton and Simon McRae and Ross Baker and Huyen A M Tran and Peter N. Mollee and G W Kershaw and Joanne M Joseph and Christopher Ward},
  journal={Thrombosis and haemostasis},
  year={2012},
  volume={107 3},
  pages={575-83}
}
Heparin-induced thrombocytopenia (HIT) remains a challenge, with diagnosis confirmed only by functional assays. The gold standard 14C-serotonin release assay (SRA) is highly sensitive but technically challenging and unsuitable for routine use. We conducted a large study to validate whole blood impedance aggregometry (WBIA) as a suitable diagnostic tool for HIT. WBIA and SRA were used to test 181 samples positive for H-PF4 antibodies by PaGIA or ELISA. Using the same high responder donor, 77… CONTINUE READING

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