Validation of ultrasonography for non-invasive assessment of diaphragm function in muscular dystrophy.

@article{Whitehead2016ValidationOU,
  title={Validation of ultrasonography for non-invasive assessment of diaphragm function in muscular dystrophy.},
  author={N. Peter Whitehead and Kenneth L. Bible and Min Jeong Kim and Guy L. Odom and Marvin E. Adams and Stanley Charles Froehner},
  journal={The Journal of physiology},
  year={2016},
  volume={594 24},
  pages={
          7215-7227
        }
}
KEY POINTS Duchenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied using the mdx mouse. The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles. mdx diaphragm force is commonly assessed ex vivo, precluding time course studies. Here we used ultrasonography to evaluate time-dependent changes in diaphragm function in vivo, by measuring diaphragm movement amplitude. In mdx mice, diaphragm amplitude decreased with age and… CONTINUE READING
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