Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis

@article{Michou2006ValidationOT,
  title={Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis},
  author={La{\"e}titia Michou and Pascal Croiseau and Elisabeth Petit-Teixeira and Sophie T{\'e}z{\'e}nas du Montcel and Isabelle Lemaire and C{\'e}line Pierlot and Jos{\'e} Francisco Sanz Osorio and Wafa Frigui and Sandra Lasbleiz and Patrick Quillet and Thomas Bardin and Bernard Prum and F. Clerget-Darpoux and François Corn{\'e}lis},
  journal={Arthritis Research & Therapy},
  year={2006},
  volume={8},
  pages={R79 - R79}
}
Recently, we proposed a classification of HLA-DRB1 alleles that reshapes the shared epitope hypothesis in rheumatoid arthritis (RA); according to this model, RA is associated with the RAA shared epitope sequence (72-74 positions) and the association is modulated by the amino acids at positions 70 and 71, resulting in six genotypes with different RA risks. This was the first model to take into account the association between the HLA-DRB1 gene and RA, and linkage data for that gene. In the… CONTINUE READING

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