[Validation of the PRIDE Scale (Primary Immunodeficiency Disease Evaluation) to Determine High Level of Suspicion for Primary Immunodeficiency Disease in Mexican Population].

Abstract

BACKGROUND Primary immunodeficiencies have a low prevalence, but their severity and high risk of mortality require a clinical approach based in diagnostic instruments that allow their early detection. OBJECTIVE To validate the PRIDE scale to determine a high level of suspicion for primary immunodeficiency diseases in Mexican population. METHODS Seventy five patients with suspicion of primary immunodeficiencies (13.9 ±11.8 years-old) were evaluated with the PRIDE scale by specialists in Allergy and Immunology in this cross-sectional study, and their results were compared with the confirmed diagnosis of primary immunodeficiency. RESULTS Kappa concordance coefficient with clinical diagnosis was 0.872, with an standard error of 0.072; CI 95% [0.73-1.013]. The scale showed sensitivity 98.3%, specificity 86.6%, positive predictive value 96.7%, negative predictive value 92.8%, positive odds ratio 7.3358 and negative odds ratio 0.0196. CONCLUSIONS PRIDE scale was concordant with the diagnosis of primary immunodeficiency in the majority of patients with a previous confirmed diagnosis. The characteristics of diagnostic accuracy provide reliability to this instrument in the scrutiny of patients with probable immunodeficiency.

Cite this paper

@article{MogicaMartnez2012ValidationOT, title={[Validation of the PRIDE Scale (Primary Immunodeficiency Disease Evaluation) to Determine High Level of Suspicion for Primary Immunodeficiency Disease in Mexican Population].}, author={Mar{\'i}a Dolores Mogica-Mart{\'i}nez and Arturo Vel{\'a}zquez-Leduc and Jos{\'e} Antonio Ortega-Martell and Carlos G{\'o}mez-Alonso and Alain Raimundo Rodr{\'i}guez-Orozco and Marisol Rico-Arroyo and Mart{\'i}n Becerril-Ngeles}, journal={Revista alergia Mexico}, year={2012}, volume={59 4}, pages={192-8} }