Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds.

@article{Marino2005ValidationOT,
  title={Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds.},
  author={Anthony M. Marino and Melissa Yarde and Hetal Patel and Saeho Chong and Praveen V. Balimane},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={297 1-2},
  pages={235-41}
}
The use of Caco-2 cells for permeability screening of discovery compounds is quite well established and serves as the "method-of-choice" across the pharmaceutical industries worldwide. The typical permeability-screening model involves growing cells on a 12 well or 24 well transwell format. In this manuscript, we report the use of Caco-2 cells grown on 96… CONTINUE READING