Validation of techniques to detect illicit heroin use in patients prescribed pharmaceutical heroin for the management of opioid dependence.

@article{Paterson2005ValidationOT,
  title={Validation of techniques to detect illicit heroin use in patients prescribed pharmaceutical heroin for the management of opioid dependence.},
  author={Sue Paterson and Nicholas Lintzeris and Timothy B. Mitchell and Rosa Cordero and Liam Nestor and John Strang},
  journal={Addiction},
  year={2005},
  volume={100 12},
  pages={
          1832-9
        }
}
BACKGROUND The clinical implementation and evaluation of heroin substitution programmes have been confounded by the lack of objective and validated biomarkers for illicit heroin use in patients prescribed pharmaceutical heroin. This study examined the capacity to detect illicit heroin use by gas chromatography-mass spectrometry (GC-MS) analysis of urine samples for the presence of opium impurities common to illicit, but not pharmaceutical heroin. AIMS To characterize the diagnostic properties… CONTINUE READING

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