Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study

@article{Winden2008ValidationOP,
  title={Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study},
  author={Annemieke W J van Winden and Marie-Christine W. Gast and Jos H. Beijnen and Emiel J. Th Rutgers and Diederick E. Grobbee and P. H. Peeters and Carla H van Gils},
  journal={BMC Medical Genomics},
  year={2008},
  volume={2},
  pages={4 - 4}
}
Serum protein profiling seems promising for early detection of breast cancer. However, the approach is also criticized, partly because of difficulties in validating discriminatory proteins. This study's aim is to validate three proteins previously reported to be discriminative between breast cancer cases and healthy controls. These proteins had been identified as a fragment of inter-alpha trypsin inhibitor H4 (4.3 kDa), C-terminal-truncated form of C3a des arginine anaphylatoxin (8.1 kDa) and… CONTINUE READING