Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.

@article{GutirrezMateo2011ValidationOM,
  title={Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.},
  author={Cristina Guti{\'e}rrez-Mateo and Pere Colls and Jorge Fernando S{\'a}nchez-Garc{\'i}a and Tom{\'a}s Escudero and Renata Prates and Kelly Ketterson and Dagan Wells and Santiago Munn{\'e}},
  journal={Fertility and sterility},
  year={2011},
  volume={95 3},
  pages={953-8}
}
OBJECTIVE To validate and determine the best array-comparative genomic hybridization (aCGH; array-CGH) protocols for preimplantation genetic screening (PGS). DESIGN Embryos had one cell removed as a biopsy specimen and analyzed by one of two array-CGH protocols. Abnormal embryos were reanalyzed by fluorescence in situ hybridization (FISH). SETTING Reference laboratory. PATIENT(S) Patients donating embryos or undergoing PGS. INTERVENTION(S) Embryo biopsy, array-CGH, FISH reanalysis… CONTINUE READING
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