Validation of methods to study the distribution and protein binding of tacrolimus in human blood.

@article{Zahir2001ValidationOM,
  title={Validation of methods to study the distribution and protein binding of tacrolimus in human blood.},
  author={Hamim Zahir and Romina A Nand and Kenneth F. Brown and Bruce N. Tattam and Andrew J. McLachlan},
  journal={Journal of pharmacological and toxicological methods},
  year={2001},
  volume={46 1},
  pages={
          27-35
        }
}
INTRODUCTION Tacrolimus is a macrolide immunosuppressant that has a narrow therapeutic index, displays considerable variability in response, and has the potential for serious drug interactions. Therapeutic drug monitoring and dose individualisation for tacrolimus is complicated but essential. Few studies have investigated the blood distribution and protein binding of tacrolimus and the results of these studies are conflicting. The aim of the present study is to establish and validate methods to… CONTINUE READING
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