Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment.

@article{Zivanovi2005ValidationOL,
  title={Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment.},
  author={Ljiljana J Zivanovi{\'c} and Mira L Ze{\vc}evi{\'c} and Slavko Markovi{\'c} and Silvana Petrovi{\'c} and Ivana Ivanovic},
  journal={Journal of chromatography. A},
  year={2005},
  volume={1088 1-2},
  pages={182-6}
}
In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation… CONTINUE READING

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