Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology.

@article{Hoffmann2011ValidationOI,
  title={Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology.},
  author={Angelika Hoffmann and Joerg Bredno and M. Wendland and Nikita Derugin and Jason Hom and Tibor Schuster and H. T. Su and Peter T. Ohara and William L. Young and Max Wintermark},
  journal={Stroke},
  year={2011},
  volume={42 7},
  pages={2054-60}
}
BACKGROUND AND PURPOSE We sought to validate the blood-brain barrier permeability measurements extracted from perfusion-weighted MRI through a relatively simple and frequently applied model, the Patlak model, by comparison with gold standard histology in a rat model of ischemic stroke. METHODS Eleven spontaneously hypertensive rats and 11 Wistar rats with unilateral 2-hour filament occlusion of the right middle cerebral artery underwent imaging during occlusion at 4 hours and 24 hours after… CONTINUE READING
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