Validation of flow cytometry analysis in the objective assessment of spermatogenesis: comparison to the quantitative testicular biopsy.

@article{Hirsch1993ValidationOF,
  title={Validation of flow cytometry analysis in the objective assessment of spermatogenesis: comparison to the quantitative testicular biopsy.},
  author={I H Hirsch and Paul McCue and D Kulp-Hugues and John R Sedor and M Flanigan},
  journal={The Journal of urology},
  year={1993},
  volume={150 2 Pt 1},
  pages={
          342-6
        }
}
Objective determination of spermatogenesis has been accomplished by quantitative testicular biopsy, which, although laborious, has served as the standard for spermatogenic assessment. Aspiration deoxyribonucleic acid (DNA) flow cytometry of the testis, however, has simplified this determination, and has correlated with indirect hormonal parameters of spermatogenesis and qualitative observations of the seminiferous epithelium. Nevertheless, this important modality has yet to be validated against… CONTINUE READING