Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model.

@article{Ferrier2007ValidationOD,
  title={Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model.},
  author={Moira C Ferrier and Hemant Sarin and Steve H. Fung and Bawarjan Schatlo and Ryszard M. Pluta and Sandeep N. Gupta and Peter L. Choyke and Edward H. Oldfield and David Thomasson and John A. Butman},
  journal={Neoplasia},
  year={2007},
  volume={9 7},
  pages={546-55}
}
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to evaluate tumor permeability, yet measurements have not been directly validated in brain tumors. Our purpose was to compare estimates of forward leakage K(trans) derived from DCE-MRI to the estimates K obtained using [(14)C]aminoisobutyric acid quantitative autoradiography ([(14)C]AIB QAR), an established method of evaluating blood-tumor barrier permeability. Both DCE-MRI and [(14)C]AIB QAR were performed in five… CONTINUE READING

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