Validation of deuterium labeled fatty acids for the measurement of dietary fat oxidation: a method for measuring fat-oxidation in free-living subjects

@article{Votruba2001ValidationOD,
  title={Validation of deuterium labeled fatty acids for the measurement of dietary fat oxidation: a method for measuring fat-oxidation in free-living subjects},
  author={SB Votruba and SM Zeddun and D Schoeller},
  journal={International Journal of Obesity},
  year={2001},
  volume={25},
  pages={1240-1245}
}
BACKGROUND: Fatty acid oxidation has frequently been measured using 13C or 14C labeled fatty acids. While providing valuable data, the breath test method is hindered by the need for a controlled environment to measure VCO2 and collect frequent breath samples. Additionally, the CO2 breath tests require the use of 13C- or 14C-acetate to correct for isotope exchange in the TCA cycle. We validated d31-palmitic acid for measuring dietary fat oxidation. When oxidized, the deuterium appears as water… CONTINUE READING
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