Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

@article{Matagne1998ValidationOC,
  title={Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.},
  author={Alain C Matagne and Henrik V Klitgaard},
  journal={Epilepsy research},
  year={1998},
  volume={31 1},
  pages={59-71}
}
Epileptogenesis induced by electrical kindling of rats appears to be superior to the acute maximal electroshock seizure (MES) test in normal animals in predicting the efficacy and adverse effect potential of drugs in patients with partial epilepsy. Unfortunately, inclusion of such kindling models in primary screening is hampered by the laborious and expensive procedure of stimulation and recording with implanted brain electrodes. Furthermore the size of the rats excludes their use in initial… CONTINUE READING

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