Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.

@article{Kovalenko2009ValidationOC,
  title={Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.},
  author={Evgeniya Kovalenko and Frank Tacke and Olav Axel Gressner and Henning Wolfgang Zimmermann and Birgit Lahme and Alfred Janetzko and Tonio Wiederholt and Thomas Berg and Tobias Carsten M{\"u}ller and Francisco Javier Cubero and Axel M. Gressner and Ralf Weiskirchen},
  journal={Journal of viral hepatitis},
  year={2009},
  volume={16 9},
  pages={612-20}
}
Clinical and experimental studies have demonstrated that connective-tissue growth factor (CTGF) expression is increased in fibrotic human liver and experimental animal models of liver fibrogenesis. CTGF has been linked to transforming growth factor-beta (TGF-beta) pathways in fibroproliferative diseases and specific polymorphisms within the CTGF gene may predispose for fibrosis in systemic sclerosis. As CTGF is detectable in various human fluids (serum, plasma and urine), it may provide… CONTINUE READING

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