Validation of an in vitro model of human saphenous vein hyperplasia.

  title={Validation of an in vitro model of human saphenous vein hyperplasia.},
  author={John J. Castronuovo and Thomas J Smith and Ray M Price},
  journal={Journal of vascular surgery},
  volume={35 1},
  • John J. Castronuovo, Thomas J Smith, Ray M Price
  • Published in Journal of vascular surgery 2002
  • Medicine
  • OBJECTIVE The purpose of this study was the validation of the physiologic appropriateness of in vitro organ culture of human saphenous vein as a model with the demonstration of the occurrence of the processes of cell proliferation, remodeling, and hyperplasia. METHODS Saphenous vein from 28 patients was cross-sectioned into seven 2-mm segments and maintained in organ culture for 2 days or 2 weeks. Three organ culture media were used: a chemically well-defined medium (RPMI-1640) and the same… CONTINUE READING

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