Validation of an immunoassay to selectively quantify the naked antibody of a new Antibody Drug Conjugate--SAR566658--for pharmacokinetic interpretation improvement.

Abstract

Given the nature of the ADCs (Antibody Drug Conjugates) as antibodies carrying cytotoxic drugs, two types of immunoassays are usually implemented to perform the analysis of preclinical and clinical study samples during the development phase. The first assay measures the conjugated antibody defined as the ADC carrying at least 1 drug molecule (i.e. drug… (More)
DOI: 10.1016/j.jim.2013.06.012

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@article{Pascual2013ValidationOA, title={Validation of an immunoassay to selectively quantify the naked antibody of a new Antibody Drug Conjugate--SAR566658--for pharmacokinetic interpretation improvement.}, author={Marie-H{\'e}l{\`e}ne Pascual and P. Verdier and Patricia Malette and Jonathan Mnich and Marie-Laure Ozoux}, journal={Journal of immunological methods}, year={2013}, volume={396 1-2}, pages={140-6} }