Validation of a two-pool model for the kinetics of beta2-microglobulin.

  title={Validation of a two-pool model for the kinetics of beta2-microglobulin.},
  author={S. Stiller and X. Q. Xu and N Gruner and Joerg Vienken and H. B. Mann},
  journal={The International journal of artificial organs},
  volume={25 5},
UNLABELLED Secondary amyloidosis due to beta-2-microglobulin (beta2-m) is a serious long-term complication in patients on regular dialysis therapy. Beta2-m can be considered a middle-molecule marker used to facilitate the assessment of dialysis efficacy. For this purpose, a validated model that calculates characteristic efficacy parameters, such as Kt/V, TAC and generation rate, is needed. There is general agreement that beta2-m-kinetics should be described by a two-pool model, but little has… CONTINUE READING