Validation of a two-compartment model of ventilation/perfusion distribution.

  title={Validation of a two-compartment model of ventilation/perfusion distribution.},
  author={Jack A. Loeppky and Arvind Caprihan and Stephen A. Altobelli and Milton V. Icenogle and Pietro Scotto and Marcos Francisco Vidal Melo},
  journal={Respiratory physiology & neurobiology},
  volume={151 1},
Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartment (MC) model. The 2C and MC estimates of V (A)/Q mismatch were obtained in 10 healthy subjects, 43 patients having chronic obstructive pulmonary disease (COPD) and in 14 dog… CONTINUE READING