Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study.

@article{Dravid2005ValidationOA,
  title={Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study.},
  author={P. Dravid and R. Bhamidipati and R. Mullangi and N. Srinivas},
  journal={Arzneimittel-Forschung},
  year={2005},
  volume={55 4},
  pages={
          239-44
        }
}
  • P. Dravid, R. Bhamidipati, +1 author N. Srinivas
  • Published 2005
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • An isocratic simple, specific, sensitive and reproducible high performance liquid chromatography (HPLC) method was developed and validated for the estimation of DRF-6196, a novel oxazolidinone in mouse plasma. This method involves a simple liquid/liquid extraction of DRF-6196 and the internal standard (IS; chlorzoxazone, CAS 95-25-0) from plasma into dichloromethane/ethyl acetate mixture that was evaporated under nitrogen. The HPLC analysis was carried out on an Inertsil ODS 2 column using 0.01… CONTINUE READING
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