Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice.

@article{Merali2003ValidationOA,
  title={Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice.},
  author={Zul Merali and Carla Levac and Hymie Anisman},
  journal={Biological psychiatry},
  year={2003},
  volume={54 5},
  pages={552-65}
}
Although numerous behavioral tests are available to assess anxiety, we introduce a simplified version of a previously established test that is exquisitely sensitive and reliable. The latency to consume a palatable snack (graham wafer crumbs) was assessed among mice in their home cage and in an unfamiliar environment, as well as in the presence or absence of predator scent. The effects of various anxiolytics and nonanxiolytics were evaluated in these paradigms. When offered the palatable snack… CONTINUE READING

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