Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study.

@article{Mitchell2010ValidationOA,
  title={Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study.},
  author={Lesley Mitchell and Moritz Lambers and Silke Flege and Gili Kenet and Valerie Li-Thiao-Te and Susanne Holzhauer and Christoph Bidlingmaier and Michael Christoph Fr{\"u}hwald and Christine Heller and Wolfgang Schmidt and Brigitte J. Pautard and Ulrike Nowak-G{\"o}ttl},
  journal={Blood},
  year={2010},
  volume={115 24},
  pages={4999-5004}
}
Among risk factors for developing thromboembolism (VTE) in children with acute lymphoblastic leukemia were Escherichia coli asparaginase, concomitant steroid use, presence of central venous lines, and thrombophilic abnormalities. Developing a predictive model for determining children at increased risk would be beneficial in targeting interventional studies to high-risk groups (HRGs). Predictive variables were incorporated into a risk assessment model, which was evaluated in 456 children and… CONTINUE READING