Validation of a novel approach for the rapid production of immunogenic virus-like particles for bluetongue virus.

@article{Stewart2010ValidationOA,
  title={Validation of a novel approach for the rapid production of immunogenic virus-like particles for bluetongue virus.},
  author={Meredith E Stewart and Yashuma Bhatia and T N Athmaran and Rob J Noad and Cristina Gastaldi and Eric Dubois and Pierre Russo and Richard Thi{\'e}ry and Corinne Sailleau and Emmanuel Breard and St{\'e}phan Zientara and Polly Roy},
  journal={Vaccine},
  year={2010},
  volume={28 17},
  pages={3047-54}
}
Bluetongue virus causes an emerging disease of ruminants, principally affecting sheep and cattle. Since 1998, there have been multiple separate outbreaks of bluetongue disease in Europe that have highlighted the need for a safe, efficacious, DIVA compliant vaccine. We report here a new baculovirus expression strategy which allowed pre-integration of the genes encoding the BTV inner capsid proteins at one baculovirus locus and those encoding the outer capsid proteins at a different locus. A… CONTINUE READING