Validation of a capillary electrophoresis assay for assessing the metabolic stability of verapamil in human liver microsomes.

Abstract

A simple CE assay for the rapid determination of the in vitro metabolic stability of verapamil in human liver microsomes has been developed and validated. Verapamil was used as the prototype drug since it is extensively metabolized in human liver microsomes. The assay showed good intra- (CV < or = 10%) and interday (CV < or = 8%) reproducibility. The… (More)

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