Validation of a Novel and Sensitive RP-HPLC Method for Simultaneous Determination of Cefixime Trihydrate and Sodium Benzoate in Powder for Oral Suspension Dosage Form

@inproceedings{Hassouna2017ValidationOA,
  title={Validation of a Novel and Sensitive RP-HPLC Method for Simultaneous Determination of Cefixime Trihydrate and Sodium Benzoate in Powder for Oral Suspension Dosage Form},
  author={Mem Hassouna},
  year={2017}
}
CFX; is chemically known as (6R,7R)-7-[[(Z)-2-(2Aminothiazol-4-yl)-2-[(carboxymethoxy) imino] acetyl] amino]-3ethenyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid trihydrate. It has a molecular formula of C16H15N5O7S2, 3H2O and a molecular weight of 507.5 [1,2] (Figure 1A). CFX is a white or almost white, slightly hygroscopic powder. Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. A 5% suspension in… 
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