Validation of a Novel and Sensitive RP-HPLC Method for Simultaneous Determination of Cefixime Trihydrate and Sodium Benzoate in Powder for Oral Suspension Dosage Form
@inproceedings{Hassouna2017ValidationOA, title={Validation of a Novel and Sensitive RP-HPLC Method for Simultaneous Determination of Cefixime Trihydrate and Sodium Benzoate in Powder for Oral Suspension Dosage Form}, author={Mem Hassouna}, year={2017} }
CFX; is chemically known as (6R,7R)-7-[[(Z)-2-(2Aminothiazol-4-yl)-2-[(carboxymethoxy) imino] acetyl] amino]-3ethenyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid trihydrate. It has a molecular formula of C16H15N5O7S2, 3H2O and a molecular weight of 507.5 [1,2] (Figure 1A). CFX is a white or almost white, slightly hygroscopic powder. Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. A 5% suspension in…
Figures and Tables from this paper
12 Citations
Modeling and optimization of a novel RP-UPLC and MCR spectrophotometric methods for simultaneous determination of five cephalosporins in spiked human plasma: Application to lean six sigma thinking hats and antimicrobial activity
- ChemistryMicrochemical Journal
- 2019
Simultaneous Quantification of Cephalexin and Sodium Benzoate in their Dosage forms by high analytical technique. Application of Lean Six Sigma and In-Vitro Dissolution studies.
- Medicine, ChemistryAnnales pharmaceutiques francaises
- 2020
Novel Spectrophotometric Methods for Simultaneous Determination of Cefixime trihydrate and Sodium benzoate in Powder for Oral Suspension Dosage form
- Chemistry
- 2017
Cefixime is generally classified as a third-generation cephalosporin antibacterial and is given orally to treat infection due to susceptible gram-positive and gram-negative bacteria. Up till now, no…
Efficient UPLC and spectrophotometric MC methods for simultaneous determination of cefixime and sodium benzoate in their dosage form and in its degradation product of cefixime-E Isomer. Application of lean six sigma and in-vitro dissolution studies
- ChemistryScientia Chromatographica
- 2019
The main objective of this study is to develop and validate a novel RP-UPLC and spectrophotometric mean centering Methods for simultaneous estimation of cefixime and sodium benzoate in their dosage…
Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder
- Medicine, ChemistryJournal of analytical methods in chemistry
- 2019
A novel HPLC method was developed and validated for simultaneous determination of potassium guaiacolsulfonate and sodium benzoate in pediatric oral powder and was proved as reliable and suitable for the intended application.
Development and validation of a simple HPTLC method for the determination of new hepatitis C subtype 4 antiviral agents in their tablet dosage form
- ChemistryJPC – Journal of Planar Chromatography – Modern TLC
- 2020
A new, simple, precise, accurate and selective high-performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of ledipasvir and…
Comparative In-Vitro Dissolution Studies for Determination of Cefixime in an Innovator Product of Suprax Powder for Oral Suspension Dosage form Using Rp-Hplc Method
- Chemistry
- 2018
Dissolution testing is an in vitro technique of great importance in formulation and development of all solid oral dosage forms and is used in all phases of development for product release and…
Determination of cefixime using a novel electrochemical sensor produced with gold nanowires/graphene oxide/electropolymerized molecular imprinted polymer.
- Materials ScienceMaterials science & engineering. C, Materials for biological applications
- 2019
Simultaneous Assay of Dexchlorpheniramine Maleate, Betamethasone, and Sodium Benzoate in Syrup by a Reliable and Robust HPLC Method
- ChemistryJournal of analytical methods in chemistry
- 2019
The simultaneous determination of betamethasone, dexchlorpheniramine maleate, and sodium benzoate in pharmaceutical syrup was done by using a simple validated HPLC method that was proven to be suitable for the intended application.
Investigation of Sodium Benzoate and Potassium Sorbate in Anti-Diabetic Herbal Drugs
- Journal of Applied Science & Process Engineering
- 2022
The objective of the study was to assess sodium benzoate and potassium sorbate in some anti-diabetic herbal drugs (ADHDs) collected from local markets using UV-Vis spectrophotometric method. Analytes…
References
SHOWING 1-10 OF 60 REFERENCES
Application of HPLC and HPTLC for the simultaneous determination of cefixime trihydrate and ambroxol hydrochloride in pharmaceutical dosage form
- Chemistry
- 2010
Two sensitive and reproducible methods are described for the quantitative determination for the simultaneous estimation of cefixime trihydrate and ambroxol hydrochloride. The first method was based…
DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF CEFIXIME TRIHYDRATE AND ITS DEGRADED PRODUCTS FORMED UNDER STRESS CONDITION OF UV LIGHT
- Chemistry
- 2012
A simple, accurate, precise and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method for the determination of cefixime trihydrate and its degraded products have been…
A novel RP-HPLC method for simultaneous determination of potassium sorbate and sodium benzoate in soft drinks using C18-bonded monolithic silica column.
- Chemistry, MedicineJournal of separation science
- 2011
Development and validation of a novel RP-HPLC method, in which a C18-bonded monolithic silica column was used as stationary phase to assay these compounds, is described for the first time.
UV-VIS SPECTROPHOTOMETRIC STUDY FOR DETERMINATION OF CEFIXIME IN PURE FORM AND IN PHARMACEUTICALS THROUGH COMPLEXATION WITH Cu(II) USING ACETATE-NaOH BUFFER IN WATER:METHANOL
- Chemistry
- 2013
UV-Vis spectroscopic method for the analysis of cefixime (CEFI)in pure form and pharmaceutical formations through complexation with Cu(II) using acetate-NaOH buffer in mixture water: methanol has…
Determination of Cefixime by a Validated Stability-Indicating HPLC Method and Identification of its Related Substances by LC-MS/MS Studies
- Chemistry, MedicineScientia pharmaceutica
- 2013
The obtained results shown in the LC-UV proposed method can be conveniently used in a quality control laboratory for routine analysis of cefixime for the assay and related substances, as well as for the evaluation of stability samples of bulk drugs.
Validated UV-Visible Spectrophotometric method for simultaneous estimation of Cefixime and Moxifloxacin in Pharmaceutical Dosage Form -
- Biology
- 2015
First order derivative spectrophotometric method developed for quantification of cefixime and moxifloxacin was validated as per ICH guideline and found to be accurate, precise and rugged.
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF CEFIXIME IN BULK DRUGS
- Chemistry
- 2001
A new technique for the quantitative determination of cefixime trihydrate in bulk drugs by high performance liquid chromatography was developed using simple reagents. Finally, chosen conditions of…
Simultaneous determination of aspartame, acesulfame-K, saccharin, citric acid and sodium benzoate in various food products using HPLC–CAD–UV/DAD
- ChemistryEuropean Food Research and Technology
- 2013
A newly developed method for simultaneous determination of aspartame, acesulfame-K, saccharin, citric acid and sodium benzoate in various diet supplements and non-alcoholic beverages in a single run…
Development and validation of UV Spectrometric Method for the Determination of Cefixime trihydrate in Bulk and Pharmaceutical Formulation
- Chemistry
- 2013
The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV-Visible spectrophotometric method for the estimation of cefixime trihydrate in…