Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.

@article{Broderick2017ValidationOR,
  title={Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.},
  author={P. Broderick and Sara E Dobbins and D. Chubb and B. Kinnersley and M. Dunlop and I. Tomlinson and R. Houlston},
  journal={Gastroenterology},
  year={2017},
  volume={152 1},
  pages={
          75-77.e4
        }
}
High-throughput sequencing analysis has accelerated searches for genes associated with risk for colorectal cancer (CRC); germline mutations in NTHL1, RPS20, FANCM, FAN1, TP53, BUB1, BUB3, LRP6, and PTPN12 have been recently proposed to increase CRC risk. We attempted to validate the association between variants in these genes and development of CRC in a systematic review of 11 publications, using sequence data from 863 familial CRC cases and 1604 individuals without CRC (controls). All cases… Expand
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