Validation of PCR-RFLP techniques for the evaluation of codon 72 of p53 and CYP1A1 gene's polymorphisms in relation with ovarian cancer in a Romanian population.

@article{Matei2012ValidationOP,
  title={Validation of PCR-RFLP techniques for the evaluation of codon 72 of p53 and CYP1A1 gene's polymorphisms in relation with ovarian cancer in a Romanian population.},
  author={Mioara Calipsoana Matei and Lucian Negură and Ludmila Liliac and Anca Mihaela Negură and Doina Azoicăi},
  journal={Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie},
  year={2012},
  volume={53 1},
  pages={47-54}
}
Epidemiological studies suggest that the onset and progression of ovarian cancer are associated with the presence of estrogens. CYP1A1 gene has two polymorphisms, which may affect the estrogens' metabolites and contribute to increased susceptibility to neoplastic transformation of ovarian cells. P53 is a tumor suppressor gene, which acts to preserve stability of human genome. Codon 72 polymorphism of p53 gene was correlated with susceptibility for ovarian cancer. The aim of our study was to… CONTINUE READING