Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: application to the study of THC distribution in tissues.

@article{Brunet2006ValidationOL,
  title={Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: application to the study of THC distribution in tissues.},
  author={Bertrand R Brunet and Carole Doucet and Nicolas Venisse and Thierry Hauet and William H{\'e}brard and Yves Papet and G{\'e}rard Mauco and Patrick Mura},
  journal={Forensic science international},
  year={2006},
  volume={161 2-3},
  pages={169-74}
}
This study presents a new animal model, the Large White Pig, which was tested for studying cannabinoids metabolism. The first step has focused on determination of plasma kinetics after injection of Delta(9)-tetrahydrocannabinol (THC) at different dosages. Seven pigs received THC by intravenous injections (50, 100 or 200 microg/kg). Plasma samples were collected during 48 h. Determination of cannabinoids concentrations were performed by gas chromatography/mass spectrometry. Results showed that… CONTINUE READING
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