Validation of Cytokeratin 19, Mammaglobin A and B in detection of breast cancer cells in the bone marrow using a nested reverse transcriptase polymerase chain reaction (RT-PCR) assay.

@article{Janku2004ValidationOC,
  title={Validation of Cytokeratin 19, Mammaglobin A and B in detection of breast cancer cells in the bone marrow using a nested reverse transcriptase polymerase chain reaction (RT-PCR) assay.},
  author={F. Janku and J. Novotn{\'y} and Z. Kleibl and P. Tesařov{\'a} and L. Petru{\vz}elka and B. Matou{\vs} and M. {\vS}afanda and M. Zemanova and P. Mare{\vs}},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 14\_suppl},
  pages={9672}
}
  • F. Janku, J. Novotný, +6 authors P. Mareš
  • Published 2004
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
9672 Background: Early hematogenous spread of occult tumor cells is a crucial event in tumor progression and formation of distant metastases. Several markers mainly cytokeratins have been validated to date using immunohistochemistry (IHC) or more sensitive reverse transcriptase polymerase chain reaction (RT-PCR). The role of Cytokeratin 19 (CK-19) remains controversial regarding it's sensitivity and specificity. In contrast Mammaglobin was reported as a breast specific marker with very high… Expand