Validation of (99m)Tc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging: Part 1: myocardial extraction and biodistribution.

@article{Mirtschink2009ValidationO,
  title={Validation of (99m)Tc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging: Part 1: myocardial extraction and biodistribution.},
  author={Peter Mirtschink and Sebastian N Stehr and Martin Walther and Jens Pietzsch and Ralf Bergmann and Hans-J{\"u}rgen Pietzsch and Johannes Weichsel and Annette Pexa and Peter Dieterich and Gerd Wunderlich and Bert Binas and Joachim Kropp and Andreas J. Deussen},
  journal={Nuclear medicine and biology},
  year={2009},
  volume={36 7},
  pages={
          833-43
        }
}
INTRODUCTION (13)C, (18)F and (123)I fatty acids (FA) are used for myocardial imaging. Recently, our group showed that [(99m)Tc]-labeled "4+1" FA are extracted into the rat and guinea pig myocardium. The present study evaluates determinants of myocardial uptake and whole body biodistribution of these FA derivatives. METHODS Studies were performed with isolated perfused hearts of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with a FAT/CD36 deficiency, as well as with heart type… Expand
Validation of (99m)Tc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging: Part 2. Subcellular distribution.
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Validation of (99m)Tc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging: Part 2. Subcellular distribution.
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Myocardial [(99m)Tc]"4+1" FA extraction reflects binding to H-FABP and membrane structures (including the mitochondrial membrane), however, the compounds do not undergo mitochondrial metabolism because they do not reach the mitochondrial matrix. Expand
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