Validation of [123I]β-CIT SPECT to Assess Serotonin Transporters In Vivo in Humans: a Double-Blind, Placebo-Controlled, Crossover Study with the Selective Serotonin Reuptake Inhibitor Citalopram

@article{Win2005ValidationO,
  title={Validation of [123I]β-CIT SPECT to Assess Serotonin Transporters In Vivo in Humans: a Double-Blind, Placebo-Controlled, Crossover Study with the Selective Serotonin Reuptake Inhibitor Citalopram},
  author={Maartje M. L. de Win and Jan B. A. Habraken and L. Reneman and Wim van den Brink and Gerard J. den Heeten and Jan Booij},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={996-1005}
}
Disturbances in the serotonin (5-HT) system are associated with various neuropsychiatric disorders. The 5-HT system can be studied in vivo by measuring 5-HT transporter (SERT) densities using 123iodine-labeled 2β-carbomethoxy-3β(4-iodophenyl)tropane ([123I]β-CIT) and single photon emission computed tomography (SPECT). Validation of this technique is important because [123I]β-CIT does not bind selectively to SERTs. Some studies have validated this technique in vivo in the human brain in SERT… CONTINUE READING
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Validity of in vivo

  • MML De Win, RAM de Jeu, K de Bruin, JBA Habraken, L Reneman, J Booij
  • 2004
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Validity of in vivo [ 123 I ] bCIT SPECT in detecting MDMA - induced neurotoxicity in rats

  • De Win MML, de Jeu RAM, K deBruin, Habraken JBA, L Reneman, J Booij
  • 2004

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