Validation method used for microbial limit test of methadone hydrochloride oral solution

@inproceedings{Weiming2011ValidationMU,
  title={Validation method used for microbial limit test of methadone hydrochloride oral solution},
  author={Wu Wei-ming},
  year={2011}
}
OBJECTIVE To set up a method for determining microbial limits in methadone hydrochloride Oral Solution.METHODS According to the Chinese Pharmacopoeia 2005 edition,the routine and culture diluting method had different percentage recovery with 5 control trains.RESULTS The recoveries were over 74% when routine test method was used with escherichia coli,staphylococcus aureus,candida albicans and aspergillus niger.The recoveries were over 81 % when culture diluting method was used with bacillus… CONTINUE READING

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