Validation and steady-state analysis of a power-law model of purine metabolism in man.

  title={Validation and steady-state analysis of a power-law model of purine metabolism in man.},
  author={Raul Curto and Eberhard O. Voit and Albert Sorribas and Marta Cascante},
  journal={The Biochemical journal},
  volume={324 ( Pt 3)},
The paper introduces a model of human purine metabolism in situ. Chosen from among several alternative system descriptions, the model is formulated as a Generalized Mass Action system within Biochemical Systems Theory and validated with analyses of steady-state and dynamic characteristics. Eigenvalue and sensitivity analyses indicate that the model has a stable and robust steady-state. The model quite accurately reproduces numerous biochemical and clinical observations in healthy subjects as… CONTINUE READING
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