Validation and preliminary application of a GC-MS method for the determination of putrescine and cadaverine in the human brain: a promising technique for PMI estimation.

@article{Pelletti2019ValidationAP,
  title={Validation and preliminary application of a GC-MS method for the determination of putrescine and cadaverine in the human brain: a promising technique for PMI estimation.},
  author={Guido Pelletti and Marco Garagnani and Rossella Barone and Rafael Boscolo-Berto and Francesca Rossi and Annalisa Morotti and Raffaella Roffi and Paolo Fais and Susi Pelotti},
  journal={Forensic science international},
  year={2019},
  volume={297},
  pages={
          221-227
        }
}
CADAVERINE AND PUTRESCINE LEVELS IN HUMAN BRAIN TISSUE FOR POSTMORTEM INTERVAL ESTIMATION
TLDR
Both Cad and Put are considered valuable biomarkers for estimating the PMI, however, put as a biomarker of PMI is more accurate than Cad, as 99.5% of the variability of Put levels was due to the progressive timing of sampling, compared to that of Cad, which was only 75.2%.
Application of Innovative TGA/Chemometric Approach for Forensic Purposes: The Estimation of the Time since Death in Contaminated Specimens
TLDR
A novel approach based on thermogravimetry and chemometrics was used to estimate the time since death in the vitreous humor and to collect a databank of samples derived from postmortem examinations after medico–legal evaluation to demonstrate the possibility to correctly predict the PMI even in contaminated samples.
Using vitreous humour and cerebrospinal fluid electrolytes in estimating post-mortem interval - an exploratory study
TLDR
K+ in VH is most accurate in estimating the PMI, with no significant improvement in accuracy when K+ in CSF is combined, suggesting the role of CSF electrolytes in estimating PMI may be very limited.
The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis
TLDR
The unexpected function of host CYP1A1 in microbiota-mediated cadaverine metabolism is revealed, with crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis, indicating that inhibiting CYP 1A1 or blocking cadaversine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal septicaemia.

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TLDR
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TLDR
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TLDR
The hypothesis that in a whole-body corpse, the distribution of bacteria from the gastrointestinal tract up to the brain in the late post-mortem interval can influence the metabolic decomposition of brain tissues is supported.
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