Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system.

@article{Clive1979ValidationAC,
  title={Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system.},
  author={David Clive and Kenneth O. Johnson and J F Spector and A G Batson and Mary M Brown},
  journal={Mutation research},
  year={1979},
  volume={59 1},
  pages={61-108}
}
The current status of the L5178Y/TK+/- leads to TK-/- mouse-lymphoma mutagenicity assay is described. Dose-survival-mutagenic response data are shown for 43 chemicals. Mutagenicity and cytotoxicity in the presence or absence of non-induced and/or Aroclor-induced rat-liver S-9 are compared for most of these chemicals, 25 of these for which usuable carcinogenicity data exist have been used to construct an approximately linear relationship between oncogenic potency in vivo and mutagenic potency in… CONTINUE READING