Validating traditional Chinese syndrome features in varied stages of chronic gastritis malignant transformation: study protocol for a cross-sectional study

@article{Zhang2018ValidatingTC,
  title={Validating traditional Chinese syndrome features in varied stages of chronic gastritis malignant transformation: study protocol for a cross-sectional study},
  author={Yin Zhang and Yue Liu and Ruiying Song and Li Zhang and Zeqi Su and Yannan Li and Runhua Chen and Ning Shi and Xia Zhao and Shi-Yu Du and Xia Ding},
  journal={BMJ Open},
  year={2018},
  volume={8}
}
Introduction The transition from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG) and gastric carcinoma (GC) is regarded as a representative disease model of gastric mucosa malignant transformation led by uncontrolled inflammation. Traditional Chinese medicine (TCM) syndrome-targeted therapies have been applied in treating chronic gastritis (CG) malignant transformation in China with satisfying efficacy. This study aims to validate TCM syndrome features in each stage of… 

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References

SHOWING 1-10 OF 39 REFERENCES

The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis

TLDR
It is indicated that JYT may have potential effects on the treatment of patients with CAG, however, due to limitations of methodological quality and small sample size of the included studies, further standardized research of rigorous design should be needed.

Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands.

TLDR
Patients with premalignant gastric lesions are at considerable risk of gastric cancer, and current surveillance of these patients is inconsistent with their cancer risk, and development of guidelines is indicated.

Current pharmacotherapy options for gastritis

TLDR
This review covers the current pharmacotherapy options for different forms of gastritis and focuses on H. pylori-induced gastritis, while primary prevention of NSAID-related gastropathy is enhanced by better education for clinicians and patients.

Review of Atrophic Gastritis and Intestinal Metaplasia as a Premalignant Lesion of Gastric Cancer

TLDR
The understanding and early diagnosis of AG and IM are very important, especially, in high incidence area of gastric cancer such as Republic of Korea, as it represents diverse results in the same nation.

Kyoto global consensus report on Helicobacter pylori gastritis and its impact on Chinese clinical practice

TLDR
The report states that the eradication of H. pylori should be regarded as the first‐line treatment for dyspepsia and H.pylori eradication before the development of pre‐neoplastic changes is recommended to reduce the risk of more serious complications of H .

Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED)

TLDR
The recommendations emphasize the increased cancer risk in patients with gastric atrophy and metaplasia and the need for adequate staging in the case of high-grade dysplasia, and they focus on treatment and surveillance indications and methods.

Stage-specific Dietary Factors Associated with the Correa Multistep and Multifactorial Process of Human Gastric Carcinogenesis

TLDR
Stage-specific dietary factors underpinning the Correa model were identified and effects of individual item-based and construct-based dietary variables aggregated by factor analysis on each stage of gastric neoplasm were assessed.

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

TLDR
A human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia, which has been linked with the supply of beta-carotene and with excessive salt intake is provided.

Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED).

TLDR
A multidisciplinary group of 63 experts from 24 countries developed evidence-based guidelines on the management of patients with precancerous conditions and lesions of the stomach by means of repeat online voting and a meeting in June 2011 in Porto, Portugal.

The gastric precancerous cascade

TLDR
The first recognized histologic change is active chronic inflammation, which may persist as such: non‐atrophic chronic gastritis, or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade.