Validating the domestic fowl as a model to investigate the pathophysiology of diclofenac in Gyps vultures.

@article{Naidoo2007ValidatingTD,
  title={Validating the domestic fowl as a model to investigate the pathophysiology of diclofenac in Gyps vultures.},
  author={Vivash Naidoo and N Duncan and Lotter Bekker and Gerry M. Swan},
  journal={Environmental toxicology and pharmacology},
  year={2007},
  volume={24 3},
  pages={
          260-6
        }
}
Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for the further characterisation of diclofenac's mechanism of toxicity. In a lethal dose study, diclofenac was shown to have an approximate intramuscular LD(50) of 9.8mg/kg in 18-week… CONTINUE READING

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